Changes in pubertal hormones, neurotransmitters and sleep patterns during sleep in girls with precocious puberty

Subjects and methods Thirty nine girls with breast development were underwent full anthropometric and, hormonal assessments. Depending on the results of Gonadotropin-Releasing Hormone (GnRH) test 22 patient, as premature telarche, and the rests, as precocious puberty, were evaluated. Nineteen age-matched, non-pubertal girls, were included as control group. Polysomnography was carried out to all patients. Levels of hormones and neurotransmitters were assessed during REM period.